Endothel.de -
Frequently Asked Questions



Q: What is the need for this presentation?

The characterization of endothelial dysfunction (ED) tremendously affects cardiology. It may lead to an earlier and more specific diagnosis yielding a better therapy or even prevention of atherothrombotic events. Endothelial dysfunction consistently accompanies cardiovascular risk factors, hypertension, diabetes, heart failure as well as coronary artery disease itself. The interface between blood, vascular muscle cells and autonomic nerve terminals seems to be poorly understood. Therefore, proliferation of knowledge about this condition is seemingly need.


Q: What are characteristics of endothelial dysfunction?

Higher vascular tone/afterload/blood pressure due to a lack of endothelial derived relaxing factor (nitric oxide). Less agonistic NO-stimulation including less flow-mediated dilation. Expression of surface proteins such as von Willebrand Factor affecting coagulation, changes in activation of membrane-bound enzymes such as ACE amongst othe



Q: What are causes of endothelial dysfunction?

Endothelial cells are adversely reacting to permanent elevations of cholesterol, oxidant stress, and glucose amongst others. In women, the cessation of vasoprotective hormones such as estrogen during menopause may lead to endothelial dysfunction. Generally, many hormones, peptides and metabolites interfere with endothelial function or smooth muscle responsiveness to endothelial factors. Endothelial dysfunction is arbitrarily defined as a poor, absent or paradox response of vascular smooth muscle cells to endothelium-dependent vasodilators. However, vascular tone is also determined by the autonomic nervous system.


Endothel.de - Fostering Endothelial Research.